Absolute Quantitative Targeted Monitoring of Potential Plasma Protein Biomarkers: A Pilot Study on Healthy Individuals.

ABSTRACT:

Background/objectives

The development of blood tests for the early detection of individual predisposition to socially significant diseases remains a pressing issue.

Methods

In this pilot study, multiple reaction monitoring mass spectrometry (MRM-MS) with a BAK-270 assay was applied for protein concentrations analysis in blood plasma from 21 healthy volunteers of the European cohort.

Results

The levels of 138 plasma proteins were reliably and precisely quantified in no less than 50% of samples. The quantified proteins included 66 FDA-approved markers of cardiovascular diseases (CVD), and other potential biomarkers of pathologies such as cancer, diabetes mellitus, and Alzheimer's disease. The analysis of individual variations of the plasma proteins revealed significant

SUBMITTER: Kononikhin AS 

PROVIDER: S-EPMC11504031 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature