Genome-Wide and Exome-Wide Association Study Identifies Genetic Underpinning of Comorbidity between Myocardial Infarction and Severe Mental Disorders.

ABSTRACT:

Background

Myocardial Infarction (MI) and severe mental disorders (SMDs) are two types of highly prevalent and complex disorders and seem to have a relatively high possibility of mortality. However, the contributions of common and rare genetic variants to their comorbidity arestill unclear.

Methods

We conducted a combined genome-wide association study (GWAS) and exome-wide association study (EWAS) approach.

Results

Using gene-based and gene-set association analyses based on the results of GWAS, we found the common genetic underpinnings of nine genes (GIGYF2, KCNJ13, PCCB, STAG1, HLA-C, HLA-B, FURIN, FES, and SMG6) and nine pathways significantly shared between MI and SMDs. Through Mendelian randomization a

SUBMITTER: Jiang B 

PROVIDER: S-EPMC11504245 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature