Guanethidine Restores Tetracycline Sensitivity in Multidrug-Resistant <i>Escherichia coli</i> Carrying <i>tetA</i> Gene.

ABSTRACT: The worrying issue of antibiotic resistance in pathogenic bacteria is aggravated by the scarcity of novel therapeutic agents. Antibiotic adjuvants offer a promising solution due to their cost-effectiveness and high efficacy in addressing this issue, such as the β-lactamase inhibitor sulbactam (a β-lactam adjuvant) and the dihydrofolate reductase inhibitor trimethoprim (a sulfonamide adjuvant). This study aimed to discover potential adjuvants for tetracyclines from a list of previously approved drugs to restore susceptibility to Escherichia coli carrying the tetA gene. We have screened guanethidine, a compound from the Chinese pharmacopoeia, which effectively potentiates the activity of tetracyclines by reversing resistance in tetA-positive Escherichia coli, enha

SUBMITTER: Zhao X 

PROVIDER: S-EPMC11504368 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature