Ambient Ozone Exposure, Semen Plasma Metabolites, and Sperm Quality Decline among Adult Men in Wuhan China.

ABSTRACT: Ambient ozone (O₃) exposure may be associated with a reduction of semen quality, yet the potential biological mechanisms remain unclear. We investigated the effects of certain seminal plasma metabolites on mediating the links between O₃ exposure and the deterioration of semen quality. The untargeted metabolomics analysis was performed on semen samples of 200 Chinese adult men to determine candidate metabolites associated with characteristics of semen quality. Mediation analysis was adopted to examine whether these metabolites modulated the links between O₃ exposure and semen quality. We found a significant reduction in sperm concentration by -28.1% (95% CI: -41.7%, -11.3%), and sperm count by -29.2% (95% CI: -43.7%, -11.0%) associated with each 10 μg/m

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11504433 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature