Linezolid Pharmacokinetics in Critically Ill Patients: Continuous Versus Intermittent Infusion.

ABSTRACT:

Background

Linezolid has been found to have considerable interindividual variability, especially in critically ill patients, which can lead to suboptimal plasma concentration. To overcome this shortcoming, several solutions have been proposed. These include using loading dose, higher maintenance doses, and dose stratification according to the patient's particularities, therapeutic drug monitoring, and drug administration via continuous infusion (CI) instead of intermittent infusion (II). In the present study, we aim to compare the pharmacokinetic (PK) parameters of linezolid after administration as II versus CI to critically ill patients.

Methods

In a prospective study conducted in an intensive care unit, we compared the same two daily doses of linezolid administered via II

SUBMITTER: Hui LA 

PROVIDER: S-EPMC11504488 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature