PET Imaging with [¹⁸F]ROStrace Detects Oxidative Stress and Predicts Parkinson's Disease Progression in Mice.

ABSTRACT: Although the precise molecular mechanisms responsible for neuronal death and motor dysfunction in late-onset Parkinson's disease (PD) are unknown, evidence suggests that mitochondrial dysfunction and neuroinflammation occur early, leading to a collective increase in reactive oxygen species (ROS) production and oxidative stress. However, the lack of methods for tracking oxidative stress in the living brain has precluded its use as a potential biomarker. The goal of the current study is to address this need through the evaluation of the first superoxide (O₂^•-)-sensitive radioactive tracer, [¹⁸F]ROStrace, in a model of late-onset PD. To achieve this goal, MitoPark mice with a dopaminergic (DA) neuron-specific deletion of transcription factor A mitochondrial (<

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC11504722 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature