From Environmental Toxicants to Antibacterial Agents: BPA Analogues Selectively Inhibit the Growth of Gram-Positive Bacteria by Disturbing Biosynthesis of the Cell Wall.

ABSTRACT: Remarkable antibacterial activity of BPA analogues especially for tetrabromobisphenol A against Staphylococcus aureus 25923 (Sa25923) and methicillin-resistant Staphylococcus aureus (MRSA) has been reported in our previous studies. However, the toxic effects of the compounds as environmental contaminants on the endocrine system limited their applications in the field of medicine and health. Given the abuse of antibiotics has led to the emergence of multiple super-resistant bacteria, we considered that structural modifications based on the BPA structure will be available for molecular designing of potential antimicrobial agents without drug resistance. In this study, to further improve the antibacterial activity and reduce the biological toxicity, we performed the computationa

SUBMITTER: Cao H 

PROVIDER: S-EPMC11504735 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature