The Functional and Prognostic Impact of TIGIT Expression on Bone Marrow NK Cells in Core Binding Factor-Acute Myeloid Leukemia Patients at Diagnosis.

ABSTRACT: Background: The effect of the expression of the newly identified immune checkpoint, T cell immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain (TIGIT) on NK cells in core binding factor-acute myeloid leukemia (CBF-AML) remains to be investigated. Methods: Fresh bone marrow samples from a total of 39 newly diagnosed CBF-AML patients and 25 healthy donors (HDs) were collected for testing the phenotype and function state of total NK, CD56^bright, and CD56^dim NK cell subsets after in vitro stimulation. Results: The frequencies of TIGIT⁺ cells in total NK, CD56^bright, and CD56^dim NK cell subsets had no significant difference between patients and HDs. TNF-α and INF-γ levels were uniformly lower in TIG

SUBMITTER: Xie DH 

PROVIDER: S-EPMC11504867 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature