Oxidative Stress in Polycystic Ovary Syndrome: Impact of Combined Oral Contraceptives.

ABSTRACT: Polycystic Ovary Syndrome (PCOS) is a complex hormonal disorder that is associated with heightened metabolic risks. While oxidative stress (OS) is known to play a role in PCOS, the precise nature of the relationship between PCOS and increased OS remains not entirely understood. Combined oral contraceptives (COCs) are the first-line treatment to regulate menstrual cycles and androgen levels, but their impact on oxidative stress requires further study. We conducted a transcriptomic analysis using RNAseq and assessed the levels of various oxidative stress (OS) markers in serum samples from women with PCOS and controls and whether they were using combined oral contraceptives (COCs), including enzymatic activities, FRAP, and 8-isoprostane (8-iso). A total of 359 genes were differentially expres

SUBMITTER: Santander N 

PROVIDER: S-EPMC11505064 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature