Spasmolytic Activity and Anti-Inflammatory Effect of Novel Mebeverine Derivatives.

ABSTRACT: Background: Irritable bowel syndrome (IBS) has a major negative influence on quality of life, causing cramps, stomach pain, bloating, constipation, etc. Antispasmodics have varying degrees of efficacy. Mebeverine, for example, works by controlling bowel movements and relaxing the muscles of the intestines but has side effects. Therefore, more efficient medication is required. Methods: In the current study, we investigated the synthesis of novel mebeverine analogs and determined ex vivo their spasmolytic and in vitro and ex vivo anti-inflammatory properties. The ability to influence both contractility and inflammation provides a dual-action approach, offering a comprehensive solution for the prevention and treatment of both conditions. Results: The results showed that a

SUBMITTER: Stoyanova M 

PROVIDER: S-EPMC11505310 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature