Evaluation of the Anti-Inflammatory/Immunomodulatory Effect of <i>Teucrium montanum</i> L. Extract in Collagen-Induced Arthritis in Rats.

ABSTRACT: The anti-inflammatory/immunomodulatory effects of Teucrium montanum L. (TM), a plant distributed in the Mediterranean region, have been insufficiently examined. The effects of the TM ethanol extract were tested in a rat collagen-induced arthritis (CIA) model of rheumatoid arthritis. LC-MS was used for the phytochemical analysis of the TM extract. Dark Agouti rats were immunized with bovine type II collagen (CII) in incomplete Freund's adjuvant for CIA, and treated with 100 or 200 mg/kg of TM extract daily via oral administration. Clinical and histopathological evaluations and a flow cytometric analysis of the phenotypic and functional characteristics of splenocytes and draining lymph node cells were performed. The cytokines in the paw tissue culture supernatants and anti-CII

SUBMITTER: Bufan B 

PROVIDER: S-EPMC11505313 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature