A Wearable Extracorporeal CO₂ Removal System with a Closed-Loop Feedback.

ABSTRACT: Extracorporeal Carbon Dioxide Removal (ECCO₂R) systems support patients with severe respiratory failure. Concurrent ambulation and physical therapy improve patient outcomes, but these procedures are limited by the complexity and size of the extracorporeal systems and rapid changes in patient metabolism and the acid-base balance. Here, we present the first prototype of a wearable ECCO₂R system capable of adjusting to a patient's changing metabolic needs. Exhaust gas CO₂ (EGCO₂) partial pressure is used as an analog for blood CO₂ partial pressure (pCO₂). Twin blowers modulate sweep gas through the AL to achieve a desired target EGCO₂. The integrated system was tested in vitro for 24 h with water, under varying simul

SUBMITTER: Zhang A 

PROVIDER: S-EPMC11505386 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature