Measurement of salivary thyroid hormones using the LC-MS/MS technique in a clinical setting.

ABSTRACT:

Background

Saliva could be an attractive alternative to blood for assessing thyroid hormonal function.

Objectives

Our goal was to determine if the levels of thyroid hormones in saliva can accurately reflect a person's thyroid status and if they consistently correlate with the levels of the same hormones in the blood.

Design

We conducted a cross-sectional study.

Methods

We enrolled a total of 109 participants with different thyroid conditions. We measured TSH (Thyroid-Stimulating Hormone), free T3 (fT3), and free T4 (fT4) in the blood using two different immunoassay methods: electrochemiluminescence immunoassay (ECLIA) and chemiluminescence immunoassay (CLIA). Saliva samples were collected using Salivette^® tubes, and then we analyzed the levels of thy

SUBMITTER: Sawicka-Gutaj N 

PROVIDER: S-EPMC11505444 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature