Impact of whole-body and skeletal muscle composition on peak oxygen uptake in heart failure: a systematic review and meta-analysis.

ABSTRACT:

Aims

Heart failure (HF) has a major impact on exercise tolerance that may (in part) be due to abnormalities in body and skeletal muscle composition. This systematic review and meta-analysis aims to assess how differences in whole-body and skeletal muscle composition between patients with HF and non-HF controls (CON) contribute to reduced peak oxygen uptake (VO₂peak).

Methods and results

The PubMed database was searched from 1975 to May 2024 for eligible studies. Cross-sectional studies with measures of VO₂peak, body composition, or muscle biopsies in HF and CON were considered. Out of 709 articles, 27 studies were included in this analysis. Compared with CON, VO₂peak [weighted mean difference (WMD): -9.96 mL/kg/min, 95% confidence interval (C

SUBMITTER: Schmid V 

PROVIDER: S-EPMC11505452 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature