Exposure to Gold Induces Autoantibodies against Nuclear Antigens in A.TL Mice.

ABSTRACT: To demonstrate causation or/and assess pathogenic mechanisms of environment-induced autoimmunity, various animal models that mimic the characteristics of the human autoimmune diseases need to be developed. Experimental studies in mice reveal the genetic factors that contribute to autoimmune diseases. Here, the immune response of two mouse strains congenic for non-H-2 genes, A.TL (H-2^tl) and A.SW (H-2^s), was evaluated after 15 weeks' exposure to gold aurothiomalate (AuTM). AuTM-treated A.TL mice showed anti-nuclear antibodies (ANA) with homogenous and/or fine speckled staining patterns and serum autoantibodies to ds-DNA, chromatin, histones, and ribonucleoproteins (RNP). Female A.TL mice showed a stronger immune response than males, as well as an increase of B cells in

SUBMITTER: Puente-Marin S 

PROVIDER: S-EPMC11505499 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature