Irisin in Reproduction: Its Roles and Therapeutic Potential in Male and Female Fertility Disorders.

ABSTRACT: The current study focused on identifying the potential of irisin in mammalian reproduction. The established role of irisin, a proteolytic product of FNDC5, in adipose tissue browning, energy metabolism, and thermogenesis suggests its role in reproductive health, often disturbed by metabolic imbalances. Various studies on mice demonstrated irisin's role in improving spermatogenesis, sperm count, and testosterone levels by influencing the hypothalamus-pituitary-gonadal axis. Moreover, in females, there is a fluctuation in levels of irisin during critical reproductive stages, including menstrual cycles, puberty, and pregnancy. Conditions like pregnancy complications, precocious puberty, and polycystic ovary syndrome (PCOS) are found to have an association with abnormal irisin levels. The pote

SUBMITTER: Khan MI 

PROVIDER: S-EPMC11505643 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature