Impact of SDF-1 and AMD3100 on Hair Follicle Dynamics in a Chronic Stress Model.

ABSTRACT: Chronic stress is a common cause of hair loss, involving inflammatory responses and changes in cellular signaling pathways. This study explores the mechanism of action of the SDF-1/CXCR4 signaling axis in chronic stress-induced hair loss. The research indicates that SDF-1 promotes hair follicle growth through the PI3K/Akt and JAK/STAT signaling pathways. Transcriptome sequencing analysis was conducted to identify differentially expressed genes in the skin of normal and stressed mice, with key genes SDF-1/CXCR4 selected through machine learning and a protein-protein interaction network established. A chronic stress mouse model was created, with injections of SDF-1 and AMD3100 administered to observe hair growth, weight changes, and behavioral alterations and validate hair follicle activity.

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11505668 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature