Early Postnatal Neuroinflammation Produces Key Features of Diffuse Brain White Matter Injury in Rats.

ABSTRACT:

Background

Perinatal infection is a major risk factor for diffuse white matter injury (dWMI), which remains the most common form of neurological disability among very preterm infants. The disease primarily targets oligodendrocytes (OL) lineage cells in the white matter but also involves injury and/or dysmaturation of neurons of the gray matter. This study aimed to investigate whether neuroinflammation preferentially affects the cellular compositions of the white matter or gray matter.

Method

Neuroinflammation was initiated by intracerebral administration of lipopolysaccharide (LPS) to rat pups at postnatal (P) day 5, and neurobiological and behavioral outcomes were assessed between P6 and P21.

Results

LPS challenge rapidly activates microglia and astrocytes, which is

SUBMITTER: Waddell J 

PROVIDER: S-EPMC11505921 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature