<i>Platycladus orientalis</i> Leaf Extract Promotes Hair Growth via Non-Receptor Tyrosine Kinase ACK1 Activation.

ABSTRACT: Platycladus orientalis is a traditional oriental herbal medicinal plant that is widely used as a component of complex prescriptions for alopecia treatment in Eastern Asia. The effect of PO on hair growth and its underlying mechanism, however, have not been demonstrated or clarified. In this study, we investigated the hair-growth-promoting effect of PO in cultured human dermal papilla cells (hDPCs). Platycladus orientalis leaf extract (POLE) was found to stimulate the proliferation of hDPCs. POLE with higher quercitrin concentration, especially, showed a high level of cellular viability. In the context of cellular senescence, POLE decreased the expression of p16 (CDKN2A) and p21(CDKN1A), which resulted in enhanced proliferation. In addition, growth factor receptors, FGFR1 and

SUBMITTER: Kim J 

PROVIDER: S-EPMC11505925 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature