Metabolic and Proteomic Profiling of Coronary Microvascular Dysfunction: Insights from Rat Models.

ABSTRACT: Coronary microvascular dysfunction (CMD) represents a principal etiological factor in ischemic heart disease. Nonetheless, a considerable subset of CMD patients experiences diagnostic delays attributable to the inadequacy of current diagnostic methodologies; which in turn results in deferred therapeutic interventions and elevated mortality rates. This study seeks to elucidate the distinct metabolic profile associated with CMD in rat models and to identify specific diagnostic markers that could enhance the diagnostic accuracy for CMD. In this study, 18 Wistar rats were randomly allocated into two groups: the sham group and the CMD group. The CMD group received injections of embolic microspheres into the left ventricle to establish a CMD model. Subsequently, non-targeted metabolomics and ace

SUBMITTER: Lu Y 

PROVIDER: S-EPMC11506044 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature