Advances and Challenges in Scoring Functions for RNA-Protein Complex Structure Prediction.

ABSTRACT: RNA-protein complexes play a crucial role in cellular functions, providing insights into cellular mechanisms and potential therapeutic targets. However, experimental determination of these complex structures is often time-consuming and resource-intensive, and it rarely yields high-resolution data. Many computational approaches have been developed to predict RNA-protein complex structures in recent years. Despite these advances, achieving accurate and high-resolution predictions remains a formidable challenge, primarily due to the limitations inherent in current RNA-protein scoring functions. These scoring functions are critical tools for evaluating and interpreting RNA-protein interactions. This review comprehensively explores the latest advancements in scoring functions for RNA-protein do

SUBMITTER: Zeng C 

PROVIDER: S-EPMC11506084 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature