<i>Toxoplasma gondii</i> macrophage migration inhibitory factor shows anti-<i>Mycobacterium tuberculosis</i> potential via AZIN1/STAT1 interaction.

ABSTRACT: Mycobacterium tuberculosis (MTB) is a pathogenic bacterium, belonging to the family Mycobacteriaceae, that causes tuberculosis (TB). Toxoplasma gondii macrophage migration inhibitory factor (TgMIF), a protein homolog of macrophage migration inhibitory factor, has been explored for its potential to modulate immune responses during MTB infections. We observed that TgMIF that interacts with CD74, antizyme inhibitor 1 (AZIN1), and signal transducer and activator of transcription 1 (STAT1) modulates endocytosis, restoration of mitochondrial function, and macrophage polarization, respectively. These interactions promote therapeutic efficacy in mice infected with MTB, thereby presenting a potential route to host-directed therapy development. Furthermore, TgMIF, in combination

SUBMITTER: Yoon C 

PROVIDER: S-EPMC11506136 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature