Mice lacking acid-sensing ion channel 2 in the medial prefrontal cortex exhibit social dominance.

ABSTRACT: Social dominance is essential for maintaining a stable society and has both positive and negative impacts on social animals, including humans. However, the regulatory mechanisms governing social dominance, as well as the crucial regulators and biomarkers involved, remain poorly understood. We discover that mice lacking acid-sensing ion channel 2 (ASIC2) exhibit persistently higher social dominance than their wild-type cagemates. Conversely, overexpression of ASIC2 in the medial prefrontal cortex reverses the dominance hierarchy observed in ASIC2 knockout (Asic2^-/-) mice. Asic2^-/- neurons exhibit increased synaptic transmission and plasticity, potentially mediated by protein kinase A signaling pathway. Furthermore, ASIC2 plays distinct functional roles in

SUBMITTER: Lin B 

PROVIDER: S-EPMC11506137 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature