Protective Effects of <i>Cervus elaphus</i> and <i>Eucommia ulmoides</i> Mixture (KGC01CE) on Muscle Loss and Function in Aged Rats.

ABSTRACT: Sarcopenia is a condition characterized by a progressive loss of muscle mass and function which are influenced by certain factors such as aging, nutritional deficiencies, and chronic diseases. Despite numerous efforts to prevent or treat sarcopenia, effective therapeutic options for this disease remain limited. This study aims to evaluate the effects of KGC01CE treatment, a mixture of Cervus elaphus (Ce) and Eucommia ulmoides (Eu), which are well-known traditional herbal medicines in Asia, on age-related muscle loss and functional decline in aged rats. KGC01CE has been found to be more effective than the individual extracts in inhibiting dexamethasone (DEX)-induced muscle atrophy and improving muscle mass and grip strength in C2C12 cells and aged rats. Moreover, animal studie

SUBMITTER: Koo GB 

PROVIDER: S-EPMC11506417 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature