Comparative Analysis of Extracellular Vesicles from Cytotoxic CD8⁺ αβ T Cells and γδ T Cells.

ABSTRACT:

Background

Although belonging to different branches of the immune system, cytotoxic CD8⁺ αβ T cells and γδ T cells utilize common cytolytic effectors including FasL, granzymes, perforin and granulysin. The effector proteins are stored in different subsets of lysosome-related effector vesicles (LREVs) and released to the immunological synapse upon target cell encounter. Notably, in activated cells, LREVs and potentially other vesicles are continuously produced and released as extracellular vesicles (EVs). Presumably, EVs serve as mediators of intercellular communication in the local microenvironment or at distant sites.

Methods

EVs of activated and expanded cytotoxic CD8⁺ αβ T cells or γδ T cells were enriched from culture supernatants by differential an

SUBMITTER: Griesel L 

PROVIDER: S-EPMC11506423 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature