Placental Tissue Calcification and Its Molecular Pathways in Female Patients with Late-Onset Preeclampsia.

ABSTRACT: Preeclampsia (PE) is a complex multisystem disease characterized by hypertension of sudden onset (>20 weeks' gestation) coupled with the presence of at least one additional complication, such as proteinuria, maternal organ dysfunction, or uteroplacental dysfunction. Hypertensive states during pregnancy carry life-threatening risks for both mother and baby. The pathogenesis of PE develops due to a dysfunctional placenta with aberrant architecture that releases factors contributing to endothelial dysfunction, an antiangiogenic state, increased oxidative stress, and maternal inflammatory responses. Previous studies have shown a correlation between grade 3 placental calcifications and an elevated risk of developing PE at term. However, little is known about the molecular pathways leading to pl

SUBMITTER: Ortega MA 

PROVIDER: S-EPMC11506500 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature