Investigating the Suitability of Mare's Milk-Derived Exosomes as Potential Drug Carriers.

ABSTRACT: Exosomes are cell-derived, membrane-surrounded particles that deliver bioactive molecules to various cells. Due to their small size, low immunogenicity, extended blood circulation, and involvement in cellular communication, they hold potential as effective drug carriers. Exosomes are present in various biological fluids, including mare's milk, a traditional drink in Central Asia. This study aims to compare exosome isolation methodologies and determine the stability of mare's milk-derived exosomes as potential therapeutic carriers. Three extraction methods-immunoprecipitation, size exclusion chromatography, and total exosome isolation-were compared in terms of exosome characteristics, purity, and content. The isolated exosomes were then loaded with quercetin, and their ability to increase i

SUBMITTER: Sergazy S 

PROVIDER: S-EPMC11506534 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature