Modulating OCA2 Expression as a Promising Approach to Enhance Skin Brightness and Reduce Dark Spots.

ABSTRACT: The oculocutaneous albinism II (OCA2) gene encodes a melanosomal transmembrane protein involved in melanogenesis. Recent genome-wide association studies have identified several single nucleotide polymorphisms within OCA2 genes that are involved in skin pigmentation. Nevertheless, there have been no attempts to modulate this gene to improve skin discoloration. Accordingly, our aim was to identify compounds that can reduce OCA2 expression and to develop a formula that can improve skin brightness and reduce hyperpigmented spots. In this study, we investigated the effects of OCA2 expression reduction on melanin levels, melanosome pH, and autophagy induction through siRNA knockdown. Additionally, we identified several bioactives that effectively reduce OCA2 ex

SUBMITTER: Cho E 

PROVIDER: S-EPMC11506640 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature