Down Syndrome in Children: A Primary Immunodeficiency with Immune Dysregulation.

ABSTRACT: Background: The multisystemic features of Down syndrome (DS) in children are accompanied by immunodeficiency, making them susceptible to infections and immune dysregulation with autoimmune, allergic, inflammatory, and hematological complications. This study was aimed at a better understanding of the abnormalities within the B and T cell compartments and their correlations with clinical immunophenotypes. Methods: Medical records of 35 DS children were retrospectively reviewed, referring to clinical symptomatology including history of infections, immune dysregulation disorders, and humoral and cellular immune response. Results: While the etiology of respiratory tract infections included typical viral and bacterial pathogens, SARS-CoV2-induced inflammatory disease and syn

SUBMITTER: Szczawinska-Poplonyk A 

PROVIDER: S-EPMC11506678 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature