Postoperative Electroacupuncture Boosts Cognitive Function Recovery after Laparotomy in Mice.

ABSTRACT: Postoperative cognitive dysfunction (POCD) is a common complication that affects memory, executive function, and processing speed postoperatively. The pathogenesis of POCD is linked to excessive neuroinflammation and pre-existing Alzheimer's disease (AD) pathology. Previous studies have shown that acupuncture improves cognition in the early phase of POCD. However, POCD can last for longer periods (up to weeks and years). The long-term effects of acupuncture are unknown. In this study, we hypothesized that electroacupuncture (EA) could reduce inflammation and cognitive dysfunction induced by laparotomy over a longer period. We characterized the effects of postoperative EA on cognitive changes and investigated the underlying molecular mechanisms in mice. Laparotomy was performed in 3-month-o

SUBMITTER: Ho YS 

PROVIDER: S-EPMC11506768 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature