Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults.

ABSTRACT: Rationale: There is no consensus on criteria to include in an asthma remission definition in real life. Factors associated with achieving remission after biologic initiation remain poorly understood. Objectives: To quantify the proportion of adults with severe asthma achieving multidomain-defined remission after biologic initiation and identify prebiologic characteristics associated with achieving remission that may be used to predict it. Methods: This was a longitudinal cohort study using data from 23 countries from the International Severe Asthma Registry. Four asthma outcome domains were assessed in the 1 year before and after biologic initiation. A priori-defined remission cutoffs were: 0 exacerbations/yr, no long-term oral corticosteroid (LTOCS), partly/wel

SUBMITTER: Perez-de-Llano L 

PROVIDER: S-EPMC11506911 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature