Genetically Predicted Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease.

ABSTRACT: Rationale: Body mass index (BMI) is associated with chronic obstructive pulmonary disease (COPD) mortality, but the underlying mechanisms are unclear. The effect of genetic variants aggregated into a polygenic score may elucidate the causal mechanisms and predict risk. Objectives: To examine the associations of genetically predicted BMI with all-cause and cause-specific mortality in COPD. Methods: We developed a polygenic score (PGS) for BMI (PGS_BMI) and tested for associations of the PGS_BMI with all-cause, respiratory, and cardiovascular mortality in participants with COPD from the COPDGene (Genetic Epidemiology of COPD), ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points), and Framingham Heart studies. We calc

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11506912 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature