Isothiocyanate-Rich Moringa Seed Extract Activates SKN-1/Nrf2 Pathway in <i>Caenorhabditis elegans</i>.

ABSTRACT: Moringa oleifera is a tropical tree that has its leaves, fruits, and seeds used as medicine and food. A standardized hydroalcoholic moringa seed extract (MSE) contains up to 40% of an isothiocyanate (MIC-1; moringin), a phytochemical known to have antioxidant and anti-inflammatory properties. Animal studies suggest that MSE may help with diseases, such as edema, colitis, obesity, and diabetes. In vitro studies have shown that MIC-1 activates the Nrf2 pathway, involved in detoxification and antioxidant pathways. To broaden the understanding of the molecular pathways regulated by MSE, we hypothesized that MSE improves the health span in Caenorhabditis elegans by activating the Nrf2 homolog (SKN-1). Our whole RNA-seq data showed that MSE at 0.1 mg/mL (100 µM MIC-1) regulated the

SUBMITTER: Farias-Pereira R 

PROVIDER: S-EPMC11507030 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature