Electron-Transferring Flavoprotein and Its Dehydrogenase Required for Fungal Pathogenicity in <i>Arthrobotrys oligospora</i>.

ABSTRACT: Electron transfer flavoprotein (ETF) plays an important function in fatty acid beta oxidation and the amino acid metabolic pathway. It can provide pathogenicity to some opportunistic fungi via modulating cellular metabolite composition. Arthrobotrys oligospora is a typical invasion fungus to nematodes. Its ETF characterization is still unknown. Here, we showed that the mutations of A. oligospora ETF (Aoetfα and Aoetfβ) and its dehydrogenase (Aoetfdh) led to severe defects in mitochondrial integrity and blocked fatty acid metabolism. The pathogenicity-associated trap structures were completely suppressed when exposed to nematode-derived ascarosides and nutrition signals, including ammonia and urea. Compared to the wild-type strain, the nematode predatory a

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11507118 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature