Comparative Analysis of Hepatic Gene Expression Profiles in Murine and Porcine Sepsis Models.

ABSTRACT: Sepsis remains a huge unmet medical need for which no approved drugs, besides antibiotics, are on the market. Despite the clinical impact of sepsis, its molecular mechanism remains inadequately understood. Recent insights have shown that profound hepatic transcriptional reprogramming, leading to fatal metabolic abnormalities, might open a new avenue to treat sepsis. Translation of experimental results from rodents to larger animal models of higher relevance for human physiology, such as pigs, is critical and needs exploration. We performed a comparative analysis of the transcriptome profiles in murine and porcine livers using the following sepsis models: cecal ligation and puncture (CLP) in mice and fecal instillation (FI) in pigs, both of which induce polymicrobial septic peritonitis, and

SUBMITTER: Halimi F 

PROVIDER: S-EPMC11507144 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature