In Vitro Methylene Blue and Carboplatin Combination Triggers Ovarian Cancer Cells Death.

ABSTRACT: Ovarian cancer presents a dire prognosis and high mortality rates, necessitating the exploration of alternative therapeutic avenues, particularly in the face of platinum-based chemotherapy resistance. Conventional treatments often overlook the metabolic implications of cancer, but recent research has highlighted the pivotal role of mitochondria in cancer pathogenesis and drug resistance. This study delves into the metabolic landscape of ovarian cancer treatment, focusing on modulating mitochondrial activity using methylene blue (MB). Investigating two epithelial ovarian cancer (EOC) cell lines, OV1369-R2 and OV1946, exhibiting disparate responses to carboplatin, we sought to identify metabolic nodes, especially those linked to mitochondrial dysfunction, contributing to chemo-resistance. Ut

SUBMITTER: da Veiga Moreira J 

PROVIDER: S-EPMC11507203 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature