Combinatorial Anti-Cancer Effect of Polypurine Reverse Hoogsteen Hairpins against <i>KRAS</i> and <i>MYC</i> Targeting in Prostate and Pancreatic Cancer Cell Lines.

ABSTRACT: Introduction: KRAS and MYC are proto-oncogenes that are strictly regulated in healthy cells that have key roles in several processes such as cell growth, proliferation, differentiation, or apoptosis. These genes are tightly interconnected, and their dysregulation can lead to cancer progression. We previously individually targeted these oncogenes using Polypurine Reverse Hoogsteen (PPRH) hairpins, mostly targeting the complementary strand of G-quadruplex-forming sequences. We validated them in vitro in different cancer cell lines with deregulated KRAS and/or MYC. In this work we focused on our understanding of the cooperative dynamics between these oncogenes, by investigating the combined impact of PPRHs targeting KRAS and MYC in pancreatic and prostate cancer cells.

SUBMITTER: Valiuska S 

PROVIDER: S-EPMC11507358 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature