Metabolomic Changes Associated with AGXT2 Genotype Variants and Stone Formation in a Colony of Cats.

ABSTRACT:

Objective

The objective of this study was to assess serum chemistries and metabolomic parameters in cats with genetic variants of the alanine-glyoxylate aminotransferase 2 (AGXT2) gene to determine abnormalities associated with urolith formation and better understand effective approaches for the treatment of cats with uroliths.

Methods

AGXT2 genotypes of 445 cats in the colony at Hill's Pet Nutrition, Inc. (Topeka, KS, USA) were assessed in a genome-wide association study. Additionally, the serum chemistries and metabolic profiles of each cat were determined, along with their lifetime history of stone incidence. Factor analysis was used as a data-reduction method for metabolites in order to perform statistical hypothesis testing and to select significant metabolites from the

SUBMITTER: Hall JA 

PROVIDER: S-EPMC11507365 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature