Characterization of Nuclear Mitochondrial Insertions in Canine Genome Assemblies.

ABSTRACT:

Background

The presence of mitochondrial sequences in the nuclear genome (Numts) confounds analyses of mitochondrial sequence variation, and is a potential source of false positives in disease studies. To improve the analysis of mitochondrial variation in canines, we completed a systematic assessment of Numt content across genome assemblies, canine populations and the carnivore lineage.

Results

Centering our analysis on the UU_Cfam_GSD_1.0/canFam4/Mischka assembly, a commonly used reference in dog genetic variation studies, we found a total of 321 Numts located throughout the nuclear genome and encompassing the entire sequence of the mitochondria. A comparison with 14 canine genome assemblies identified 63 Numts with presence-absence dimorphism among dogs, wolves, and a coyo

SUBMITTER: Schall PZ 

PROVIDER: S-EPMC11507379 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature