Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss <i>Bifidobacterium breve</i> BBr60 Intervention: A Randomized Controlled Trial.

ABSTRACT: Probiotics, known for regulating gut microbiota, may aid those with overweight or obesity, but their mechanisms require more research. This study involved 75 overweight or obese young adults, randomly assigned to either a Bifidobacterium breve BBr60 (BBr60) group or a placebo group. Both groups received diet guidance and took either BBr60 (1 × 10¹⁰ CFU/day) or a placebo for 12 weeks. Researchers analyzed body composition, serum glucose, lipids, liver and kidney function, comprehensive metabolome, and intestinal homeostasis before and after the intervention. After 12 weeks, BBr60 significantly reduced weight and BMI compared to pretreatment levels and outperformed the placebo. The BBr60 group also showed improved blood biochemistry, with notably lower fasting blood glucose

SUBMITTER: Bai Z 

PROVIDER: S-EPMC11507383 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature