Metabolomic Analysis of Histological Composition Variability of High-Grade Serous Ovarian Cancer Using ¹H HR MAS NMR Spectroscopy.

ABSTRACT: In this work, the HR MAS NMR (high-resolution magic-angle spinning nuclear magnetic resonance) spectroscopy technique was combined with standard histological examinations to investigate the metabolic features of high-grade serous ovarian cancer (HGSOC) with a special focus on the relation between a metabolic profile and a cancer cell fraction. The studied group consisted of 44 patients with HGSOC and 18 patients with benign ovarian tumors. Normal ovarian tissue was also excised from 13 control patients. The metabolic profiles of 138 tissue specimens were acquired on a Bruker Avance III 400 MHz spectrometer. The NMR spectra of the HGSOC samples could be discriminated from those acquired from the non-transformed tissue and were shown to depend on tumor purity. The most important features tha

SUBMITTER: Skorupa A 

PROVIDER: S-EPMC11507550 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature