Outdoor Air Pollution Relates to Amygdala Subregion Volume and Apportionment in Early Adolescents.

ABSTRACT:

Background

Outdoor air pollution is associated with an increased risk for psychopathology. Although the neural mechanisms remain unclear, air pollutants may impact mental health by altering limbic brain regions, such as the amygdala. Here, we examine the association between ambient air pollution exposure and amygdala subregion volumes in 9-10-year-olds.

Methods

Cross-sectional Adolescent Brain Cognitive Development^SM (ABCD) Study^® data from 4,473 participants (55.4% male) were leveraged. Air pollution was estimated for each participant's primary residential address. Using the probabilistic CIT168 atlas, we quantified total amygdala and 9 distinct subregion volumes from T1- and T2-weighted images. First, we examined how criteria pollutants (i.e., fine pa

SUBMITTER: Morrel J 

PROVIDER: S-EPMC11507665 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature