Comparison of whole-brain task-modulated functional connectivity methods for fMRI task connectomics.

ABSTRACT: Higher brain functions require flexible integration of information across widely distributed brain regions depending on the task context. Resting-state functional magnetic resonance imaging (fMRI) has provided substantial insight into large-scale intrinsic brain network organisation, yet the principles of rapid context-dependent reconfiguration of that intrinsic network organisation are much less understood. A major challenge for task connectome mapping is the absence of a gold standard for deriving whole-brain task-modulated functional connectivity matrices. Here, we perform biophysically realistic simulations to control the ground-truth task-modulated functional connectivity over a wide range of experimental settings. We reveal the best-performing methods for different types of task desi

SUBMITTER: Masharipov R 

PROVIDER: S-EPMC11507666 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature