Enhanced Hippocampal Spare Capacity in Q175DN Mice Despite Elevated mHTT Aggregation.

ABSTRACT:

Background

Huntington's disease (HD) is a neurodegenerative disease resulting in devastating motor, cognitive, and psychiatric deficits. The striatum is a brain region that controls movement and some forms of cognition and is most significantly impacted in HD. However, despite well-documented deficits in learning and memory in HD, knowledge of the potential implication of other brain regions such as the hippocampus remains limited.

Objective

Here, we study the comparative impact of enhanced mHTT aggregation and neuropathology in the striatum and hippocampus of two HD mouse models.

Methods

We utilized the zQ175 as a control HD mouse model and the Q175DN mice lacking the PGK-Neomycin cassette generated in house. We performed a comparative characterization of the neuropa

SUBMITTER: Solem MA 

PROVIDER: S-EPMC11507687 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature