Identification and Targeting of Regulators of SARS-CoV-2-Host Interactions in the Airway Epithelium.

ABSTRACT: Although the impact of SARS-CoV-2 in the lung has been extensively studied, the molecular regulators and targets of the host-cell programs hijacked by the virus in distinct human airway epithelial cell populations remain poorly understood. This is in part ascribed to the use of nonprimary cell systems, overreliance on single-cell gene expression profiling that does not ultimately reflect protein activity, and bias toward the downstream effects rather than their mechanistic determinants. Here we address these issues by network-based analysis of single cell transcriptomic profiles of pathophysiologically relevant human adult basal, ciliated and secretory cells to identify master regulator (MR) protein modules controlling their SARS-CoV-2-mediated reprogramming. This uncovered chromatin remod

SUBMITTER: Dirvin B 

PROVIDER: S-EPMC11507692 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature