Diversity of ancestral brainstem noradrenergic neurons across species and multiple biological factors.

ABSTRACT: The brainstem region, locus coeruleus (LC), has been remarkably conserved across vertebrates. Evolution has woven the LC into wide-ranging neural circuits that influence functions as broad as autonomic systems, the stress response, nociception, sleep, and high-level cognition among others. Given this conservation, there is a strong possibility that LC activity is inherently similar across species, and furthermore that age, sex, and brain state influence LC activity similarly across species. The degree to which LC activity is homogenous across these factors, however, has never been assessed due to the small sample size of individual studies. Here, we pool data from 20 laboratories (1,855 neurons) and show diversity across both intrinsic and extrinsic factors such as species, age, sex and br

SUBMITTER: Kelberman MA 

PROVIDER: S-EPMC11507722 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature