Autonomic and Immune Stress Response Networks in Patients Living With HIV.

ABSTRACT:

Background and objectives

Stress response systems are frequently dysregulated in patients with chronic inflammatory disorders. Pre-clinical studies have demonstrated direct influences of the sympathetic and vagal/parasympathetic branches of the autonomic nervous system (ANS) on the immune system. However, these connections have not been examined in humans. We hypothesized that the subtype and severity of autonomic neuropathy (AN) would predict immune phenotypes with distinct clinical and demographic characteristics in people living with HIV.

Methods

This is a cross-sectional study of 79 adult people with a history of well-controlled HIV on stable combination antiretroviral treatment (CART) recruited from a primary care clinic network within the Mount Sinai Health System in N

SUBMITTER: Mueller BR 

PROVIDER: S-EPMC11507734 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature