Exploring voltage-gated sodium channel conformations and protein-protein interactions using AlphaFold2.

ABSTRACT: Voltage-gated sodium (Na_V) channels are vital regulators of electrical activity in excitable cells, playing critical roles in generating and propagating action potentials. Given their importance in physiology, Na_V channels are key therapeutic targets for treating numerous conditions, yet developing subtype-selective drugs remains challenging due to the high sequence and structural conservation among Na_V family members. Recent advances in cryo-electron microscopy have resolved nearly all human Na_V channels, providing valuable insights into their structure and function. However, limitations persist in fully capturing the complex conformational states that underlie Na_V channel gating and modulation. This study explores the capability of A

SUBMITTER: Lopez-Mateos D 

PROVIDER: S-EPMC11507785 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature