Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates.

ABSTRACT: The amygdaloid complex mediates learning, memory, and emotions. Understanding the cellular and anatomical features that are specialized in the amygdala of primates versus other vertebrates requires a systematic, anatomically-resolved molecular analysis of constituent cell populations. We analyzed five nuclear subdivisions of the primate amygdala with single-nucleus RNA sequencing in macaques, baboons, and humans to examine gene expression profiles for excitatory and inhibitory neurons and confirmed our results with single-molecule FISH analysis. We identified distinct subtypes of FOXP2 ⁺ interneurons in the intercalated cell masses and protein-kinase C-δ interneurons in the central nucleus. We also establish that glutamatergic, pyramidal-like neurons are transcriptionally

SUBMITTER: Totty MS 

PROVIDER: S-EPMC11507838 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature