A hypothalamic circuit mechanism underlying the impact of stress on memory and sleep.

ABSTRACT: Stress profoundly affects sleep and memory processes. Stress impairs memory consolidation, and similarly, disruptions in sleep compromise memory functions. Yet, the neural circuits underlying stress-induced sleep and memory disturbances are still not fully understood. Here, we show that activation of CRH^PVN neurons, similar to acute restraint stress, decreases sleep and impairs memory in a spatial object recognition task. Conversely, inhibiting CRH^PVN neurons during stress reverses stress-induced memory deficits while slightly increasing the amount of sleep. We found that both stress and stimulation of CRH^PVN neurons activate neurons in the lateral hypothalamus (LH), and that their projections to the LH are critical for mediating stress-induced memory defic

SUBMITTER: Wiest A 

PROVIDER: S-EPMC11507874 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature